Chiral Brønsted acid-catalyzed asymmetric dearomative spirocyclization of alkynyl thioethers
Xin-Yang Fan, Jiacheng Li, Ji‐Jia Zhou, Bo Zhou, Long‐Wu Ye
Abstract
A chiral Brønsted acid-catalyzed asymmetric dearomative spirocyclization of alkynyl thioethers has been developed, leading to the green and atom-economical preparation of chiral sprio[4.5]decan-6-ones in good yields with high enatioselectivities.
Topics & Concepts
CatalysisBrønsted–Lowry acid–base theoryChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesOxidative Organic Chemistry Reactions