Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First <i>In Vivo</i> Experiments
Angelo Frei, Alysha G. Elliott, Alex Kan, Hue Dinh, Stefan Bräse, Alice E. Bruce, Mitchell R. M. Bruce, Feng Chen, Dhirgam Humaidy, Nicole Jung, Anna King, Peter G. Lye, Hanna K. Maliszewska, Ahmed M. Mansour, Dimitris Matiadis, María Paz Muñoz, Tsung-Yu Pai, Shyam Pokhrel, Peter J. Sadler, Marina Sagnou, M.K. Taylor, Justin J. Wilson, Dean Woods, Johannes Zuegg, Wieland Meyer, Amy K. Cain, Matthew A. Cooper, Mark A. T. Blaskovich
Abstract
infection model. These findings showcase that the structural and chemical diversity of metal-based compounds can be an invaluable tool in the development of new drugs against infectious diseases.
Topics & Concepts
Galleria mellonellaAntifungalIn vivoAntimicrobialCytotoxicityMicrobiologyToxicityMetalChemistryBiologyPharmacologyIn vitroBiochemistryOrganic chemistryBiotechnologyVirulenceGeneFerrocene Chemistry and ApplicationsSynthesis and Biological EvaluationMetal complexes synthesis and properties