Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum
Heather J. Painter, Joanne M. Morrisey, Michael W. Mather, Lindsey Orchard, Cuyler Luck, Martin J. Smilkstein, Michael K. Riscoe, Akhil B. Vaidya, Manuel Llinás
Abstract
The continued emergence of drug-resistant Plasmodium falciparum parasites hinders global attempts to eradicate malaria, emphasizing the need to identify new antimalarial drugs. Attractive targets for chemotherapeutic intervention are the cytochrome (cyt) bc 1 complex, which is an essential component of the mitochondrial electron transport chain (mtETC) required for ubiquinone recycling and mitochondrially localized dihydroorotate dehydrogenase (DHODH) critical for de novo pyrimidine synthesis.
Topics & Concepts
Plasmodium falciparumDrug resistanceDrugMalariaBiologyVirologyPharmacologyMedicineMicrobiologyImmunologyBiochemical and Molecular ResearchHIV/AIDS drug development and treatmentPneumocystis jirovecii pneumonia detection and treatment