Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP-1 formation
Yuehua You, Wanying Tan, Yongzheng Guo, Minghao Luo, Fei‐Fei Shang, Yong Xia, Suxin Luo
Abstract
Progesterone directly upregulated endothelial nitric oxide synthase (eNOS) expression in human endothelial cells. Progesterone augmented eNOS promoter activity through a progesterone receptor A- and specificity protein-1-dependent manner. Antagonism of the progesterone receptor reduced eNOS expression and impaired vasodilation in rats.
Topics & Concepts
Endothelial nitric oxide synthaseNitric oxide synthaseProgesterone receptorChemistryCell biologyATP synthaseReceptorNuclear receptorNitric oxideEndocrinologyInternal medicineBiologyBiochemistryMedicineEnzymeGeneEnosTranscription factorEstrogen receptorCancerBreast cancerEstrogen and related hormone effectsNitric Oxide and Endothelin EffectsMenopause: Health Impacts and Treatments