Microneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia
Kousalya Prabahar, Udhumansha Ubaidulla, Nehal M. Elsherbiny, Mona Qushawy
Abstract
< 0.05). Anagen/telogen ratio was significantly affected by NLC and NLC-MN, which was 2.22 ± 0.34, 1.24 ± 0.18 respectively compared to 0.26 ± 0.08 for animal group treated with testosterone. The reversal of androgen-induced hair loss in animals treated with β-sitosterol was a sign of hair follicle dominance in the anagenic growth phase. However, NLC-MN delivery system has shown significant enhancement of hair growth in rats. From these experimental data, it can be concluded that NLC incorporated MN transdermal system have potential in effective treatment of androgenic alopecia.
Topics & Concepts
TransdermalBioavailabilityMaterials sciencePharmacologyIn vivoBox–Behnken designChromatographyBiomedical engineeringChemistryResponse surface methodologyMedicineBiologyBiotechnologyAdvancements in Transdermal Drug DeliveryDermatology and Skin DiseasesContact Dermatitis and Allergies