Highly efficient photothermal branched Au–Ag nanoparticles containing procyanidins for synergistic antibacterial and anti-inflammatory immunotherapy
Hanchi Wang, Dongyang Wang, Huimin Huangfu, Siyu Chen, Qiuyue Qin, Sicong Ren, Yidi Zhang, Li Fu, Yanmin Zhou
Abstract
contributes to the preparation of a nanoparticle branched structure that improves the photothermal efficiency and helps PTT achieve an excellent antibacterial effect and avoid periodontal tissue damage. PC regulates host immunity by eliminating intracellular ROS, inhibiting inflammatory factors, and regulating macrophage polarisation in periodontal disease sites. It enhances the host's resistance to bacterial inflammation. AuAg-PC exerted an excellent anti-inflammatory effect and promoted tissue repair in animal periodontal inflammation models. Hence, AuAg-PC significantly combats periodontal pathogens and shows great application potential in the photothermal-assisted immunotherapy of periodontitis. This design provided a new controllable and efficient treatment platform for controlling persistent inflammation infection and regulating immunity.