Footprint-free gene mutation correction in induced pluripotent stem cell (iPSC) derived from recessive dystrophic epidermolysis bullosa (RDEB) using the CRISPR/Cas9 and piggyBac transposon system
Munenari Itoh, Shiho Kawagoe, Katsuto Tamai, Hidemi Nakagawa, Akihiko Asahina, Hirotaka James Okano
Topics & Concepts
CRISPRInduced pluripotent stem cellCas9Genome editingBiologyMutationGeneticsGeneGene mutationEmbryonic stem cellSkin and Cellular Biology ResearchPluripotent Stem Cells ResearchGenetic and rare skin diseases.