Litcius/Paper detail

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases

Nicole S. Persky, Desiree Hernandez, M. Do Carmo, Lisa Brenan, Ofir Cohen, Shunsuke Kitajima, Utthara Nayar, Amy K. Walker, Sasha Pantel, Yilin Lee, Jonathon Cordova, Murugappan Sathappa, Cong Zhu, Tikvah K. Hayes, Prahlad T. Ram, Priya Pancholi, Tarej Mikkelsen, David A. Barbie, Xiaoping Yang, Rizwan Haq, Federica Piccioni, David E. Root, Cory M. Johannessen

2020Nature Structural & Molecular Biology63 citationsDOI

Topics & Concepts

KinomeKinaseDrug discoveryMutantBiologyComputational biologyMutagenesisDrug developmentDrug resistanceCell biologyDrugBiochemistryGeneticsPharmacologyGeneMelanoma and MAPK PathwaysProtein Degradation and InhibitorsCancer therapeutics and mechanisms