Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases
Nicole S. Persky, Desiree Hernandez, M. Do Carmo, Lisa Brenan, Ofir Cohen, Shunsuke Kitajima, Utthara Nayar, Amy K. Walker, Sasha Pantel, Yilin Lee, Jonathon Cordova, Murugappan Sathappa, Cong Zhu, Tikvah K. Hayes, Prahlad T. Ram, Priya Pancholi, Tarej Mikkelsen, David A. Barbie, Xiaoping Yang, Rizwan Haq, Federica Piccioni, David E. Root, Cory M. Johannessen
Topics & Concepts
KinomeKinaseDrug discoveryMutantBiologyComputational biologyMutagenesisDrug developmentDrug resistanceCell biologyDrugBiochemistryGeneticsPharmacologyGeneMelanoma and MAPK PathwaysProtein Degradation and InhibitorsCancer therapeutics and mechanisms