Overcoming <i>peri</i>- and <i>ortho</i>-selectivity in C–H methylation of 1-naphthaldehydes by a tunable transient ligand strategy
Yujian Mao, Jing Jiang, Dandan Yuan, Xiuzhen Chen, Yanan Wang, Lihong Hu, Yinan Zhang
Abstract
-iridacycle. Importantly, to demonstrate the synthetic utility of this method, we show that this strategy can serve as a platform for the synthesis of multi-substituted naphthalene-based bioactive molecules and natural products.
Topics & Concepts
Transient (computer programming)Ligand (biochemistry)MethylationPeriSelectivityChemistryCombinatorial chemistryComputer scienceReceptorMedicineInternal medicineGeneBiochemistryOperating systemCatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques