Synthesis of New Cisplatin Derivatives from Bile Acids
Barbara Seroka, Zenon Łotowski, Agnieszka Hryniewicka, Lucie Rárová, Rafał R. Siciński, Aneta M. Tomkiel, Jacek W. Morzycki
Abstract
A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.
Topics & Concepts
CytotoxicityCisplatinChemistryIn vitroMoleculeBile acidPlatinumCombinatorial chemistryCytotoxic T cellStereochemistryBiochemistryOrganic chemistryBiologyCatalysisChemotherapyGeneticsDrug Transport and Resistance MechanismsMetal complexes synthesis and propertiesHIV/AIDS drug development and treatment