HSD1787, a Tetrahydro-3<i>H</i>-Pyrazolo[4,3-<i>f</i>]Quinoline Compound Synthesized via Povarov Reaction, Potently Inhibits Proliferation of Cancer Cell Lines at Nanomolar Concentrations
Neetu Dayal, Modi Wang, Herman O. Sintim
Abstract
]quinoline core is therefore a new scaffold that could be developed into potent anticancer therapeutics against difficult-to-treat cancers.
Topics & Concepts
QuinolineChemistryCell cultureCancer researchTriple-negative breast cancerCancerCell growthCancer cell linesCancer cellMelanomaStereochemistryBreast cancerPharmacologyMedicineBiochemistryBiologyInternal medicineOrganic chemistryGeneticsMulticomponent Synthesis of HeterocyclesSynthesis and biological activityClick Chemistry and Applications