Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats
Zuyang Zhang, Tianhua Chen, Wei Liu, Jiepeng Xiong, Liangdong Jiang, Mingjiang Liu
Abstract
, paeonol treatment promoted M2-polarization and repressed M1-polarization in macrophages, thereby improving the repair of cell damage induced by high glucose. Paeonol accelerates the healing of diabetic ulcers by promoting M2 macrophage polarization and inhibiting M1 macrophage polarization.
Topics & Concepts
PaeonolMacrophage polarizationM2 MacrophageWound healingAngiogenesisInflammationCD31Vascular endothelial growth factorProinflammatory cytokineTumor necrosis factor alphaMedicineCancer researchMacrophageChemistryPathologyImmunologyBiochemistryIn vitroVEGF receptorsAlternative medicineWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementPressure Ulcer Prevention and Management