Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1
Alfredo Martínez-Gutiérrez, Irene Fernández-Duran, Anna Marazuela-Duque, Nicolás G. Simonet, Ibraheem Yousef, Immaculada Martínez‐Rovira, Josefina Martínez-Hoyos, Alejandro Vaquero
Abstract
, suggesting that SIRT1 is a downstream effector of SA signaling specifically in the response to cellular senescence. Our study not only uncovers a shikimic acid/SIRT1 signaling pathway that prevents cellular senescence, but also reinforces the role of sirtuins as key regulators of cell proteostasis.
Topics & Concepts
SenescenceCell biologyNAD+ kinaseSirtuinSirtuin 1AutophagyDNA damageDownregulation and upregulationSIRT2ProteostasisBiologyShikimic acidChemistryBiochemistryEnzymeApoptosisGeneDNASirtuins and Resveratrol in MedicineBiochemical effects in animalsAutophagy in Disease and Therapy