Synthesis of Diverse 4‐Pyrrolin‐2‐ones by Electrochemically Induced Dehydrogenative Regioselective Cyclization of 3‐Aza‐1,5‐dienes and 1,3‐Dicarbonyl Compounds
Xing Ji, Run He, Lou Shi, Shaoguang Sun, Deqiang Liang
Abstract
Abstract A practical and mild electrochemical dehydrogenative regioselective cyclization method has been established for the synthesis of 4‐pyrrolin‐2‐ones using 3‐aza‐1,5‐dienes and 1,3‐dicarbonyl compounds as substrates. This protocol is catalyst‐free, metal‐free, and does not require oxidizing agents. It exhibits wide substrate compatibility and can be easily scaled up to the gram scale.
Topics & Concepts
RegioselectivityChemistryCombinatorial chemistryOrganic chemistryMedicinal chemistryStereochemistryCatalysisRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods