Manganese Acts as an Environmental Inhibitor of Pseudomonas aeruginosa Biofilm Development by Inducing Dispersion and Modulating c-di-GMP and Exopolysaccharide Production via RbdA
Soyoung Park, Jozef Dingemans, Karin Sauer
Abstract
While diverse environmental conditions such as the availability of metal ions have been shown to affect biofilm development, little is known about the mechanism. Here, we demonstrate that Mn 2+ affects Pseudomonas aeruginosa biofilm development by stimulating phosphodiesterase RbdA activity to reduce the signaling molecule c-di-GMP levels, thereby hindering polysaccharide production and biofilm formation but enhancing dispersion.
Topics & Concepts
BiofilmBiologyPseudomonas aeruginosaMicrobiologyPseudomonadaceaeBacteriaCell biologyBiochemistryGeneticsBacterial biofilms and quorum sensingOral microbiology and periodontitis researchWater Treatment and Disinfection