Fusobacterium nucleatum and Colorectal Cancer
Rongrong Li, Jilu Shen, Yuanhong Xu
Abstract
Abstract: Fusobacterium nucleatum ( F.n ) is an oral anaerobic gram-negative bacillus that can colonize into the colon tissues through bloodstream infection. F.n have been found to be involved in both the occurrence and metastasis of colorectal cancer (CRC) through regulating immune response, virulence factor, oncogenic microRNAs, intestinal metabolites, DNA damage and other mechanisms. Therefore, F.n can be as an important pathogenic risk factor and a possible biomarker of CRC. Based on this, we have summarized the potential relationship between F.n and CRC to provide reference for the targeted therapy of CRC. Keywords: Fusobacterium nucleatum , colorectal cancer, gut microbiome, mechanisms, biomarker
Topics & Concepts
Fusobacterium nucleatumColorectal cancerMedicineVirulenceBiomarkerMetastasisVirulence factorImmune systemCancerCancer researchFusobacteriumOral CancersImmunityMicrobiologyDistant metastasisImmunologyBiologyAnaerobic bacteriaDiseaseOtolaryngology and Infectious DiseasesGut microbiota and healthStreptococcal Infections and Treatments