Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration
Yuyao Wang, Yan Li, Jie Feng, Weijing Liu, Yandong Li, Jun Liu, Qianqian Yin, Hong Lian, Lihui Liu, Yu Nie
Abstract
Mydgf promotes cardiomyocyte proliferation by activating c-Myc/FoxM1 pathway and improves heart regeneration both in neonatal and adult mice after cardiac injury, providing a potential target to reverse cardiac remodeling and heart failure.
Topics & Concepts
Regeneration (biology)Paracrine signallingCell biologyCardiac function curveWestern blotBiologyCell growthRecombinant DNACancer researchHeart failureMolecular biologyMedicineInternal medicineGeneReceptorBiochemistryGeneticsCongenital heart defects researchCardiac Fibrosis and RemodelingTissue Engineering and Regenerative Medicine