RBC-derived nanosystem with enhanced ferroptosis triggered by oxygen-boosted phototherapy for synergized tumor treatment
Wenjun Liu, Jieyuan Zhang, Jieyuan Zhang, Liang Ding, Weifeng Ni, Junjie Yuan, Haijun Xiao, Jingwei Zhang, Jingwei Zhang
Abstract
RDV enriched with hemoglobin co-delivers Ce6 and SRF into cancer cells for boosting oxygen and providing iron, which leads to enhanced PDT and stronger ferroptosis therapy.
Topics & Concepts
Photodynamic therapyPhotosensitizerCancer researchIn vivoCancer cellChemistryCancer therapyApoptosisReactive oxygen speciesIn vitroCytotoxicityProgrammed cell deathCancerPharmacologyMedicineBiochemistryBiologyBiotechnologyInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismPhotodynamic Therapy Research Studies