Unveiling the promising anticancer activity of palladium(<scp>ii</scp>)–aryl complexes bearing diphosphine ligands: a structure–activity relationship analysis
Giovanni Tonon, Matteo Mauceri, Enrico Cavarzerani, Rachele Piccolo, Claudio Santo, Nicola Demitri, Laura Orian, Pablo A. Nogara, João Batista Teixeira da Rocha, Vincenzo Canzonieri, Flavio Rizzolio, Fabiano Visentin, Thomas Scattolin
Abstract
Pd–aryl complexes bearing a wide range of disphosphine, aryl and halide ligands were synthesized. Their remarkable in vitro and ex vivo anticancer activity seems to involve DNA as the main biotarget and an intrinsic apoptotic cell death mechanism.
Topics & Concepts
ArylPalladiumChemistryBearing (navigation)ApoptosisIn vitroStereochemistryEx vivoCombinatorial chemistryBiochemistryCatalysisOrganic chemistryCartographyAlkylGeographyMetal complexes synthesis and propertiesClick Chemistry and ApplicationsCatalytic Alkyne Reactions