New-Onset Diabetes in COVID-19: Time to Frame Its Fearful Symmetry
Stella Papachristou, Iliana Stamatiou, Anca Pantea Stoian, Νικόλαος Παπάνας
Abstract
There is increasing evidence that coronavirus disease 2019 (COVID-19) may lead to new-onset diabetes mellitus (DM). This may occur even in patients without predisposing factors for impaired glucose metabolism. Both impaired pancreatic insulin secretion and insulin resistance have been implicated as underlying mechanisms. Importantly, new-onset hyperglycaemia is associated with worse prognosis in patients with COVID-19. Indeed, its prognosis may be even more sinister than in patients with pre-existing DM. More research data and knowledge are currently being collected to improve our insights into this constellation and to guide therapies in clinical reality.
Topics & Concepts
MedicineDiabetes mellitusCoronavirus disease 2019 (COVID-19)Insulin resistanceDisease2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)InsulinBioinformaticsIntensive care medicineInternal medicineEndocrinologyVirologyInfectious disease (medical specialty)BiologyOutbreakCOVID-19 Clinical Research StudiesDiabetes and associated disordersDiabetes Management and Research