Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs
Sharna-kay Daley, Geoffrey A. Cordell
Abstract
An overview is presented of the well-established role of alkaloids in drug discovery, the application of more sustainable chemicals, and biological approaches, and the implementation of information systems to address the current challenges faced in meeting global disease needs. The necessity for a new international paradigm for natural product discovery and development for the treatment of multidrug resistant organisms, and rare and neglected tropical diseases in the era of the Fourth Industrial Revolution and the Quintuple Helix is discussed.
Topics & Concepts
Drug discoveryDiseaseNatural productData scienceBusinessBiotechnologyRisk analysis (engineering)MedicineBiologyComputer scienceBioinformaticsPathologyBiochemistryComputational Drug Discovery MethodsMicrobial Natural Products and BiosynthesisSynthesis and biological activity