Assessment of romosozumab efficacy in the treatment of postmenopausal osteoporosis: Results from a mechanistic PK-PD mechanostat model of bone remodeling
Madge Martin, Vittorio Sansalone, David M. L. Cooper, Mark R. Forwood, Peter Pivonka
Topics & Concepts
SclerostinMedicineOsteoporosisBone remodelingPharmacodynamicsPharmacokineticsDiscontinuationPopulationInternal medicinePharmacologyWnt signaling pathwayChemistrySignal transductionBiochemistryEnvironmental healthBone health and osteoporosis researchBone health and treatmentsAlkaline Phosphatase Research Studies