Correlation of fecal calprotectin and patient-reported outcome measures in patients with ulcerative colitis
Nagesh Kamat, Sudheer K. Vuyyuru, Saurabh Kedia, Pabitra Sahu, Bhaskar Kante, Peeyush Kumar, Mukesh Kumar Ranjan, Mukesh Kumar Singh, Sambuddha Kumar, Vikas Sachdev, Govind Makharia, Vineet Ahuja
Abstract
tent validity, construct validity and subsequently further validation. The inflammatory bowel disease control (IBD control) questionnaire is one such questionnaire developed and validated according to the recommended guidelines. Even though recently there has been an increasing demand for the use of PROs, their role in predicting mucosal activity is not clear. Fecal calprotectin (FCP) is a sensitive diagnostic marker for disease activity in UC, 5 and numerous studies have shown a significant correlation of FCP with endoscopic and histological healing. Recently updated Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) consensus also recommends inflammatory markers like C-reactive protein (CRP) and FCP as intermediate targets. There are no studies to show the correlation of PROs with inflammatory markers like FCP. Hence, we designed this cross-sectional study to demonstrate the correlation between PROs and FCP.