Predicting the presence and mechanism of busulfan drug-drug interactions in hematopoietic stem cell transplantation using pharmacokinetic interaction network–based molecular structure similarity and network pharmacology
Chenxia Hao, Xiaoqin Ma, Lining Wang, Weixia Zhang, Jiong Hu, Jingjing Huang, Wanhua Yang
Topics & Concepts
BusulfanPregnane X receptorPharmacologyPharmacokineticsDrug interactionDrugGSTP1Hematopoietic stem cell transplantationMedicineChemistryTransplantationNuclear receptorInternal medicineGlutathioneBiochemistryTranscription factorGeneEnzymeDrug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismPregnancy and Medication Impact