Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy
Adriano B. Chaves‐Filho, Almut Schulze
Topics & Concepts
Cytotoxic T cellLiver X receptorChimeric antigen receptorCholesterolTumor microenvironmentCancer researchCancer cellBiologymTORC1T cellCell biologyCancerSignal transductionEndocrinologyImmunologyNuclear receptorPI3K/AKT/mTOR pathwayBiochemistryImmune systemIn vitroTumor cellsGeneGeneticsTranscription factorCholesterol and Lipid MetabolismImmune Cell Function and InteractionAtherosclerosis and Cardiovascular Diseases