Recent Advances in Cell-Based Therapies for Ischemic Stroke
Satoshi Suda, Chikako Nito, Shoji Yokobori, Yuki Sakamoto, Masataka Nakajima, Kota Sowa, Hirofumi Obinata, Kazuma Sasaki, Sean I. Savitz, Kazumi Kimura
Abstract
Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke.