Inherent directing group-enabled Co(<scp>iii</scp>)-catalyzed C–H allylation/vinylation of isoquinolones
Sachin, Tamanna Sharma, Devesh Chandra, Sumit, Upendra Sharma
Abstract
Co(III)-catalysed site-selective C8-allylation and vinylation of isoquinolones with allyl acetate and vinyl acetates has been accomplished. The oxo group of isoquinolone has been utilised as an inherent directing group. Based on preliminary mechanistic studies, a plausible mechanism for the developed reaction has also been delineated. Broad substrate scope with good to excellent yields and post-synthetic transformations of allylated and vinylated isoquinolines highlight the importance of the reaction.
Topics & Concepts
ChemistryCatalysisSubstrate (aquarium)Scope (computer science)Combinatorial chemistryFunctional groupReaction conditionsVinyl acetateReaction mechanismGroup (periodic table)Organic chemistryOceanographyGeologyCopolymerComputer sciencePolymerProgramming languageCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Biological Activity