Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt
Deena Jalal, Mariam G. Elzayat, Aya A. Diab, Hend E. El-Shqanqery, Omar Samir, Usama Bakry, Reem Hassan, Mervat Elanany, Lobna Shalaby, Ahmed A. Sayed
Abstract
detection of antimicrobial-resistant genes and virulence factors revealed a strong correlation between certain virulence genes and mortality as well as several point mutations in outer membrane proteins contributing to colistin resistance. Detection of CRISPR/Cas sequences in the majority of the samples was strongly correlated with the presence of prophage sequences and associated with failure of bacteriophage therapy. Altogether, understanding the genetic makeup of circulating A. baumannii is essential for better management of outbreaks.
Topics & Concepts
Acinetobacter baumanniiColistinMultilocus sequence typingAntibiotic resistanceMicrobiologyBiologyMultiple drug resistanceDrug resistanceVirulenceAntibioticsOutbreakMedicineAntimicrobialEffluxPediatric cancerResistomePlasmidPolymyxinTypingMolecular epidemiologyMutationCancerGeneVirologyCarbapenemInfection controlAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceInfections and bacterial resistance