The peroxisome proliferator-activated receptor agonist rosiglitazone specifically represses tumour metastatic potential in chromatin inaccessibility-mediated FABP4-deficient gastric cancer
Qi‐Yue Chen, Xiaobo Huang, Yajun Zhao, Hua‐Gen Wang, Jiabin Wang, Lichao Liu, Ling-Qian Wang, Qing Zhong, Jianwei Xie, Jian-Xian Lin, Jun Lü, Long‐Long Cao, Mi Lin, Ru‐Hong Tu, Chao‐Hui Zheng, Ping Li, Chang‐Ming Huang
Abstract
Background: Efforts to prevent recurrence in gastric cancer (GC) patients are limited by current incomplete understanding of the pathological mechanisms. The present study aimed to identify novel tumour metastasis-associated genes and investigate potential value of these genes in clinical diagnosis and therapy. Methods: RNA sequencing was performed to identify differentially expressed genes related to GC metastasis. The expression and prognostic significance of fatty acid binding protein 4 (FABP4) were evaluated in two independent cohorts of GC patients. Chromatin immunoprecipitation sequencing, diverse mouse models and assays for transposase-accessible chromatin with high-throughput sequencing were used to investigate the roles and mechanisms of action of FABP4.