Effects of a semi-interpenetrating network hydrogel loaded with oridonin and DNase-I on the healing of chemoradiotherapy-induced oral mucositis
Yuxue Pan, Mengyuan Wang, Peng Wang, Hongliang Wei, Xiangjuan Wei, Dongmei Wang, Yongwei Hao, Yongxue Wang, Hongli Chen
Abstract
wound repair effect, microbiological assays, H&E and Masson staining supported the non-toxicity of ORI/DNase-I/IPN, as well as its ability to accelerate the healing of oral ulcers and reduce inflammation. Overall, ORI/DNase-I/IPN demonstrated a therapeutic effect on OM in rats by significantly accelerating the healing process. These findings provide new insights into possible therapies for OM.
Topics & Concepts
MucositisChemoradiotherapyChemistryWound healingSelf-healing hydrogelsSurgeryMedicineChemotherapyPolymer chemistryOral health in cancer treatmentBioactive Natural Diterpenoids ResearchSynthetic Organic Chemistry Methods