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The evolution of machine learning potentials for molecules, reactions and materials

Junfan Xia, Yaolong Zhang, Bin Jiang

2025Chemical Society Reviews50 citationsDOI

Abstract

data faithfully to continuous and symmetry-preserving mathematical forms, MLPs have enabled accurate and efficient atomistic simulations in a large scale from first principles. In this review, we provide an overview of the evolution of MLPs in the past two decades and focus on the state-of-the-art MLPs proposed in the last a few years for molecules, reactions, and materials. We discuss some representative applications of MLPs and the trend of developing universal potentials across a variety of systems. Finally, we outline a list of open challenges and opportunities in the development and applications of MLPs.

Topics & Concepts

Computer scienceMoleculeNanotechnologyCognitive scienceChemistryMaterials sciencePsychologyOrganic chemistryMachine Learning in Materials ScienceComputational Drug Discovery MethodsProtein Structure and Dynamics
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