High Levels of Cyclic Diguanylate Interfere with Beneficial Bacterial Colonization
Ruth Y. Isenberg, David G. Christensen, Karen L. Visick, Mark J. Mandel
Abstract
There is substantial interest in studying cyclic diguanylate (c-di-GMP) in pathogenic and environmental bacteria, which has led to an accepted paradigm in which high c-di-GMP levels promote biofilm formation and reduce motility. However, considerably less focus has been placed on understanding how this compound contributes to beneficial colonization.
Topics & Concepts
BiofilmMotilityColonizationMicrobiologyBiologyBacteriaVibrioHost (biology)Cell biologyGeneticsBacterial biofilms and quorum sensingVibrio bacteria research studiesYersinia bacterium, plague, ectoparasites research