Within-Host Genotypic and Phenotypic Diversity of Contemporaneous Carbapenem-Resistant Klebsiella pneumoniae from Blood Cultures of Patients with Bacteremia
Shaoji Cheng, Giuseppe Fleres, Liang Chen, Guojun Liu, Binghua Hao, Anthony Newbrough, Eileen Driscoll, Ryan K. Shields, Kevin M Squires, Tingyu Chu, Barry N. Kreiswirth, M. Hong Nguyen, Cornelius J. Clancy
Abstract
The long-standing paradigm for pathogenesis of bacteremia is that, in most cases, a single organism passes through a bottleneck and establishes itself in the bloodstream (single-organism hypothesis). In keeping with this paradigm, standard practice in processing positive microbiologic cultures is to test single bacterial strains from morphologically distinct colonies.
Topics & Concepts
BacteremiaKlebsiella pneumoniaeMicrobiologyBiologyGenotypeBlood cultureOrganismPhenotypeBloodstream infectionBottleneckGeneGeneticsAntibioticsEscherichia coliEmbedded systemComputer scienceAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility TestingVibrio bacteria research studies