Platelet, Plasma, Urinary Tryptophan-Serotonin-Kynurenine Axis Markers in Hyperacute Brain Ischemia Patients: A Prospective Study
Luigi Francesco Saccaro, Fernando Pico, Marie-Laure Chadenat, O. Richard, Jean-Marie Launay, Brigitte Bastenaire, Philippe Jullien, Jérôme Lambert, Vincent Feuga, Maryline Macquet, Jacques Callebert, Yves Lambert, Odile Spreux‐Varoquaux
Abstract
We observed, for the first time, a hyperacute dysregulation of the serotonergic axis, and hyperacute and long-lasting activation of the tryptophan-kynurenine pathway in brain ischemia.
Topics & Concepts
KynurenineSerotonergicKynurenine pathwaySerotoninMedicineInternal medicineUrinary systemPlateletEndocrinologyTryptophanPlatelet-poor plasmaIschemiaStroke (engine)Prospective cohort studyPlatelet activationPlatelet-rich plasmaChemistryReceptorBiochemistryAmino acidMechanical engineeringEngineeringTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsMental Health Research Topics