Natural Polymers Decorated MOF-MXene Nanocarriers for Co-delivery of Doxorubicin/pCRISPR
Navid Rabiee, Mojtaba Bagherzadeh, Maryam Jouyandeh, Payam Zarrintaj, Mohammad Reza Saeb, Masoud Mozafari, Mohammadreza Shokouhimehr, Rajender S. Varma
Abstract
26% for the HeLa cell line. Also, a considerable drug payload of 35.7% was achieved, which would be because of the interactions between the nanocarrier and the doxorubicin. In this unprecedented report pertaining to the synthesis of MXene assisted by a MOF and high-gravity technique, the methodology and the optimized ensuing MXene/MOF-5 nanosystems can be further developed for the co-delivery of drug/gene in animal models.
Topics & Concepts
NanocarriersHeLaViability assayChitosanMTT assayDrug deliveryBioavailabilityCytotoxicityHEK 293 cellsNanotechnologyGene deliveryChemistryBiophysicsMaterials scienceCellPharmacologyBiochemistryTransfectionIn vitroBiologyGeneMXene and MAX Phase MaterialsGraphene and Nanomaterials ApplicationsAdvanced biosensing and bioanalysis techniques