Biomimetic Small-Molecule Self-Assembly of PI3K inhibitor integrated with immunomodulator to amplify anticancer efficacy
Zhe Zhang, Lanjiao Hou, Zixiang Yu, Zesha Xu, Shurong Li, Yingying Wang, Hongyan Liu, Baoquan Zhao, Rui Liu, Wei Wang, Bo Du, Yuxu Zhong, Dexin Kong
Topics & Concepts
Cancer researchTumor microenvironmentChemistryPI3K/AKT/mTOR pathwayProinflammatory cytokineImmune systemCancer cellMacrophage polarizationPharmacologyToxicityCancerMacrophageMedicineIn vitroImmunologySignal transductionInflammationBiochemistryInternal medicineTumor cellsOrganic chemistryImmune cells in cancerPhagocytosis and Immune RegulationImmunotherapy and Immune Responses