Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression
Chun‐Chia Cheng, Hsin-Chi Lin, Ya-Wen Chiang, Jungshan Chang, Zong‐Lin Sie, Bi-Ling Yang, Ken‐Hong Lim, Cheng‐Liang Peng, Ai-Sheng Ho, Yi-Fang Chang
Topics & Concepts
Granzyme BCytotoxic T cellCD8Granzyme AGranzymeCancer researchNicotineBiologyImmunologyChemistryMolecular biologyImmune systemPerforinBiochemistryIn vitroNeuroscienceImmunotherapy and Immune ResponsesImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers