Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing
Chayanika Biswas, Qinning Wang, Sebastiaan J. van Hal, David W. Eyre, Bernard Hudson, Catriona Halliday, Krystyna Mazsewska, Alice Kizny Gordon, Andie Lee, László Irinyi, Christopher H. Heath, Arunaloke Chakrabarti, Nelesh P. Govender, Wieland Meyer, Vitali Sintchenko, Sharon C.‐A. Chen
Abstract
Abstract Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.