Structural basis of TRPV5 regulation by physiological and pathophysiological modulators
Edwin C. Fluck, Aysenur Torun Yazici, Tibor Rohács, Vera Y. Moiseenkova‐Bell
Abstract
is the primary modulator of channel gating, yet PKA controls TRPV5 activity by preventing CaM binding and channel inactivation. Our data provide detailed molecular mechanisms for regulation of TRPV5 by two key extrinsic modulators, low pH and PKA.
Topics & Concepts
Transient receptor potential channelHomeostasisRegulatorParathyroid hormoneChemistryGatingCalmodulinCell biologyPhosphorylationBiophysicsBiochemistryInternal medicineEndocrinologyBiologyCalciumReceptorEnzymeMedicineOrganic chemistryGeneIon Channels and ReceptorsMagnesium in Health and DiseaseIon channel regulation and function