Highly Regioselective Synthesis of <i>N</i>‐β‐trifluoromethyl 2‐pyridones via <i>anti</i>‐Markovnikov Hydroamination of α‐(trifluoromethyl)styrenes with 2‐pyridones
Yi Zhang, Zhudi Sun, Jingjing He, Yupian Deng, Ying Liu, Pai Zheng, Song Cao
Abstract
Abstract A novel and facile method for the synthesis of N ‐β‐CF 3 ‐substituted 2‐pyridones via hydroamination of α‐(trifluoromethyl)styrenes with 2‐pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N ‐(β‐trifluoromethyl‐β‐arylethyl)pyridin‐2(1 H )‐ones in moderate to good yields with excellent N ‐regioselectivity.
Topics & Concepts
HydroaminationTrifluoromethylRegioselectivityChemistryMarkovnikov's ruleCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods