The role of receptor‐type protein tyrosine phosphatases in cancer
Zhengyuan Lv, Tianming Wang, Xin Cao, Mengting Sun, Yuan Qu
Abstract
Abstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers.
Topics & Concepts
Protein tyrosine phosphataseReceptor tyrosine kinaseTyrosine phosphorylationTyrosineROR1Cancer researchPhosphorylationCarcinogenesisAngiogenesisCancerPhosphataseSignal transductionProto-oncogene tyrosine-protein kinase SrcReceptorBiologyTumor progressionTyrosine kinaseCell biologyChemistryBiochemistryPlatelet-derived growth factor receptorGeneticsGrowth factorProtein Tyrosine PhosphatasesGalectins and Cancer BiologyRNA modifications and cancer