ALKBH5 activates FAK signaling through m6A demethylation in <i>ITGB1</i> mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer
Rui Sun, Lin Yuan, Yi Jiang, Yicong Wan, Xiaolling Ma, Jing Yang, Guodong Sun, Shulin Zhou, Hui Wang, Jiangnan Qiu, Lin Zhang, Wenjun Cheng
Abstract
The ALKBH5/m6A-ITGB1/FAK signalling axis is important in ovarian cancer lymphangiogenesis and LN metastasis. Antibodies that block ITGB1 and FAK kinase-inhibitors are promising anti-metastatic agents.
Topics & Concepts
Cancer researchLymphangiogenesisBiologyMetastasisOncogeneGene knockdownOvarian cancerCancerMolecular biologyCell cycleGeneBiochemistryGeneticsRNA modifications and cancerCancer-related gene regulationHVDC Systems and Fault Protection