Redox-Neutral Ni-Catalyzed sp<sup>3</sup> C–H Alkylation of α-Olefins with Unactivated Alkyl Bromides
Mikkel B. Buendia, Bradley Higginson, Søren Kegnæs, Søren Kramer, Rubén Martı́n
Abstract
A light-induced redox-neutral Ni-catalyzed sp3 C–H alkylation of unactivated alkenes with alkyl bromides possessing β-hydrogens is described herein. The method is distinguished by its simplicity, wide scope, and exquisite regio- and chemoselectivity profile, thus offering an entry point to forge sp3–sp3 architectures.
Topics & Concepts
AlkylationCatalysisAlkylChemistryRedoxMedicinal chemistryNickelOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions