A novel multi-carboxyl functionalized MOF platform for effective photodynamic therapy with hypoxia modulation based on prominent self-oxygen generation
Guorui Gao, Yifan Wang, Yu Jiang, Shiping Luo, Mengnan Li, Yanyu Cao, Yu Ma, Bo Tang
Abstract
We for the first time, using a multicarboxyl modification strategy, integrated high density Fe-based catalytic centers and the clinically available ICG molecule into the same stable MOFs and obtained a novel self-oxygen generation enhanced PDT platform.
Topics & Concepts
Photodynamic therapyOxygenModulation (music)Hypoxia (environmental)ChemistryMaterials scienceChemical engineeringNanotechnologyOrganic chemistryEngineeringAestheticsPhilosophyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisMetal-Organic Frameworks: Synthesis and Applications