Two novel Pd thiosemicarbazone complexes as efficient and selective antitumoral drugs
Tania Hidalgo, David Fabra, Raul Allende, Ana I. Matesanz, Patricia Horcajada, Tarita Biver, Adoración G. Quiroga
Abstract
Two Palladium complexes are presented as a promising alternative to platinum drugs disadvantages, controlling the speciation and limiting toxicity. Their interaction vs. biological targets and their efficiency are demonstrated, being more specific than the benchmark cisplatin drug.
Topics & Concepts
SemicarbazoneCisplatinLimitingPalladiumPlatinumChemistryCombinatorial chemistryToxicityDrugPharmacologyGenetic algorithmBenchmark (surveying)StereochemistryBiochemistryBiologyOrganic chemistryChemotherapyGeneticsMechanical engineeringCatalysisEngineeringGeographyGeodesyMetal complexes synthesis and propertiesLanthanide and Transition Metal ComplexesMagnetism in coordination complexes