Cell-type-specific silence in thalamocortical circuits precedes hippocampal sharp-wave ripples
Anna R. Chambers, Christoffer Nerland Berge, Koen Vervaeke
Abstract
imaging and optogenetics, we show that, 1-2 s before SWRs, superficial inhibition and thalamocortical input in RSC is reduced. We propose that pyramidal dendrites experience decreased local inhibition and subcortical interference in a seconds-long time window preceding SWRs. This may aid communication of weak and sparse SWR-aligned excitation between the hippocampus and neocortex and promote the strengthening of memory-related connections.
Topics & Concepts
NeocortexRetrosplenial cortexOptogeneticsHippocampal formationNeuroscienceHippocampusChromatin structure remodeling (RSC) complexBiological neural networkPyramidal cellBiologyPsychologyHistoneNucleosomeBiochemistryGeneNeural dynamics and brain functionNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics research