Exploring inclusion complex of an anti-cancer drug (6-MP) with β-cyclodextrin and its binding with CT-DNA for innovative applications in anti-bacterial activity and photostability optimized by computational study
Modhusudan Mondal, Shatarupa Basak, Salim Ali, Debadrita Roy, Subhadeep Saha, Biswajit Ghosh, Narendra Nath Ghosh, Khusboo Lepcha, Kanak Roy, Mahendra Nath Roy
Abstract
The complexation of an essential anti-cancer drug called 6-Mercaptopurine monohydrate with β-cyclodextrin was investigated for enhancing bioavailability.
Topics & Concepts
ChemistryCyclodextrinNuclear chemistrySolubilityIn vitroAntibacterial activityFourier transform infrared spectroscopyStoichiometryThermal stabilityCancer cellMTT assayCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryCancerChemical engineeringBacteriaMedicineGeneticsEngineeringBiologyInternal medicinePregnancy and Medication ImpactHIV/AIDS drug development and treatmentDrug Solubulity and Delivery Systems