Well-defined, air- and moisture-stable palladium–imidazo[1,5-<i>a</i>]pyridin-3-ylidene complexes: a versatile catalyst platform for cross-coupling reactions by L-shaped NHC ligands
Tongliang Zhou, Pengcheng Gao, Elwira Bisz, Błażej Dziuk, Roger A. Lalancette, Roman Szostak, Michal Szostak
Abstract
]pyridin-3-ylidene ligands through Ni-catalyzed Kumada cross-coupling is disclosed. The method obviates chromatographic purification at any of the steps, resulting in a facile and modular access to ImPy ligands. We anticipate that well-defined [Pd-ImPy] complexes will find broad utility in organic synthesis and catalysis for activation of unreactive bonds.
Topics & Concepts
ChemistryCatalysisSteric effectsLigand (biochemistry)Combinatorial chemistrySubstituentReactivity (psychology)PalladiumCoupling reactionStereochemistryMedicinal chemistryOrganic chemistryPathologyReceptorBiochemistryMedicineAlternative medicineN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods