Click-Grafting of Cardanol onto Mesoporous Silica/Silver Janus Particles for Enhanced Hemostatic and Antibacterial Performance
Jiawen Chen, Kexin Chen, Qinglin Li, Guofa Dong, Jie Ai, Haiqing Liu, Qinhui Chen
Abstract
Janus particles with obvious chemical compartition can perform their functions independently, so they have attracted much attention in biomedical materials. Herein, a mesoporous silica/silver Janus nanoparticle modified with cardanol (C-MSN@Ag) was designed and synthesized via redox and click chemical reactions and was further evaluated as a highly efficient hemostatic dressing. This Janus structure endowed C-MSN@Ag with both prominent hemostatic and antibacterial performance. The hemostatic time of C-MSN@Ag on rat liver laceration was up to 40% shorter than that of MSN and MSN@Ag because of adhesion of phenolic compounds on the tissue and the blocking effect of the hydrophobic alkyl chains from cardanol. Besides, C-MSN@Ag could promote coagulation by forming a three-dimensional network with fibrin more quickly than MSN and MSN@Ag. Additionally, due to the released silver ions and phenolic hydroxyl groups of cardanol, C-MSN@Ag exhibited a broad-spectrum antibacterial rate (∼99%) against both Escherichia coli and Staphylococcus aureus. C-MSN@Ag also possessed non-cytotoxicity. This work not only provides a way for the fabrication of silica-based Janus hemostatic agents by the atom-economical click reaction but also gives a direction for the application of the sustainable naturally occurring cardanol.