Palladium-Catalyzed Perfluoroalkylative Carbonylation of 2-Allylaryl Trifluoromethanesulfonates: Base-Controlled Selective Access to β-Perfluoroalkyl Amides
Youcan Zhang, Zhipeng Bao, Jian‐Xing Xu, Xiao‐Feng Wu
Abstract
A palladium-catalyzed perfluoroalkylative carbonylation of 2-allylaryl trifluoromethanesulfonates has been developed. A range of 2-allyl trifluoromethanesulfonates, perfluoroalkyl halides, and amines were applied in this tandem procedure to provide the corresponding β-perfluoroalkyl amides with good functional group tolerance and high chemoselectivity. The final products were controlled by the base applied.
Topics & Concepts
ChemoselectivityChemistryCarbonylationPalladiumCatalysisHalideBase (topology)TandemFunctional groupOrganic chemistryCombinatorial chemistryCarbon monoxideMathematical analysisComposite materialPolymerMaterials scienceMathematicsFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Biological Evaluation